Studies
This page includes both current and completed BPSU studies. You can browse studies by speciality, year or status using the filters below, and access study summaries, protocols, publications and patient information materials where available. Together, these studies provide an important evidence base for clinical practice, service development, public health policy and future research.
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Androgen insensitivity syndrome (AIS)
Surveillance of AIS wanted to determine the frequency of complete androgen insensitivity syndrome (annual incidence plus prevalence). To determine in such cases what proportion presents as a bilateral inguinal hernia in a female infant. To determine the frequency of partial androgen insensitivity syndrome. The survey also aimed to provide information on associations between androgen insensitivity syndrome and other disorders, describe the range of phenotypic abnormalities in partial androgen insensitivity syndrome, and present optimal diagnostic procedures and management options.
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Acute Flaccid Paralysis
This survey aimed to investigate whether paralytic "wild" polio still existed in the British Isles. The team investigated the clinical and laboratory features of new cases of acute flaccid paralysis to identify any caused by poliovirus and, if so, to distinguish "wild" strains from vaccine-like strains.
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Chemistry set poisoning
The BPSU facilitated the surveillance of chemistry set poisoning in 1991. The team collected information on the substances involved, the packaging and associated risk factors and outcomes.
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Rett syndrome
The aim of the this BPSU study was to identify associations which may assist genetic investigation. Doctors were invited to report classic and atypical cases born on or after 1 January 1975.
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Congenital rubella
Congenital rubella is a notifiable disease. However, to support the surveillance of this condition, the ISOSS team commissions the British Paediatric Surveillance Unit (BPSU) to collect notifications from clinicians throughout England. Monitoring of these cases enables ISOSS to identify whether maternal infections were acquired abroad or at home, and to maintain awareness of this condition.
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Acute rheumatic fever 1
In the mid-1980's there were reports of outbreaks of Acute rheumatic fever(ARF) in several areas of the United States and subsequently similar reports emerged from Europe. In January 1988, under the auspices of the BPSU, all paediatricians in the British Isles were asked to report any new cases of ARF seen during 1987; only nine were reported. Case ascertainment via such retrospective reporting was felt to be unsatisfactory so a 12 month prospective study was undertaken during 1990 with the main aim of determining the annual incidence of ARF in children less than 16 years in the British Isles.
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Measles, mumps, rubella-meningoencephalitis (MMR)
Active surveillance of mumps vaccine-associated meningoencephalitis was initiated in 1990 through the BPSU. BPSU reporters in the British Isles were asked to report cases of meningoencephalitis in children under 16 years of age occurring within six weeks of receiving the MMR vaccine.
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Congenital toxoplasmosis 1
At the time of the study, there was a debate about whether there should be a prenatal screening programme for toxoplasmosis in the UK. This study aimed to determine the number of cases in the British Isles.
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High order births
This survey, conducted January - December 1989, asked BPSU reporters to report involvement they had in the management of triplets or higher order births.
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Vitamin K deficiency bleeding 1 (haemorrhagic disease of the newborn)
This two year study looked into the the haemorrhagic disease of the new-born. The study was able to confirm that the disease remained a preventable cause of mortality and morbidity in the British Isles.
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Insulin dependent diabetes mellitus in under-fifteens (Childhood onset diabetes)
This study focused on establishing the incidence rates for both the transient and permanent forms of neonatal diabetes (information which is not available from the literature). In addition, they hoped this study would allow comparisons between the clinical, physiological and genetic characteristics of the children presenting with these two conditions.
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Galactosaemia
Ascertainment of cases of classical galactosaemia over a three year period in the UK and the Republic of Ireland.
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