Encephalitis in early childhood (2 months – 3 years)
This study was undertaken from October 1998 to September 2001. Encephalopathy in early childhood made a substantial contribution to chronic neurological disability, and the impact on individual families, frequently exacerbated by diagnostic uncertainty, may be devastating. At the time of surveillance, the causes were largely unknown. This study wanted to determine the aetiology of encephalitis in children from 2 months old to their third birthday, and in particular, the role of infection with HHV-6 and HHV-7.
Lead investigator
Dr KN Ward
About the study
Encephalopathy in early childhood made a substantial contribution to chronic neurological disability, and the impact on individual families, frequently exacerbated by diagnostic uncertainty, may be devastating. At the time of surveillance, the causes were largely unknown.
The National Childhood Encephalopathy Study (1976-1979) suggested an unidentified viral illness was a likely cause (i.e. an encephalitis).
Identification of the causative agent(s) would have helped to curtail unnecessary investigation, rationalise treatment and improve the reliability of prognosis. New laboratory methods were available to provide a more accurate diagnosis of possible agents causing encephalitis.
Two newly discovered viruses, HHV-6 and HHV-7, were obvious candidates for investigation.
This study wanted to determine the aetiology of encephalitis in children from 2 months old to their third birthday, and in particular, the role of infection with HHV-6 and HHV-7.
Duration
October 1998 – September 2001
Published papers
Ward KN, Andrews NJ, Verity CM, Miller E, Ross EM. Human herpesviruses-6 and -7 each cause significant neurological morbidity in Britain and Ireland. Arch Dis Child. 2005 Jun;90(6):619-23. doi: 10.1136/adc.2004.062216. PMID: 15908629; PMCID: PMC1720457.
BPSU 16th Annual report 2001 – 2002
Support Group
Encephalitis Support Group
Web: https://www.encephalitis.info Email: mail@encephalitis.