Past studies
Find information about previous studies with BPSU over its history. This includes the key findings, as well as any publications associated with the study. These display in order of the study's start date, and you can use the filter to find by category or start date.
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Congenital and hospitalised neonatal varicella
BPSU surveillance of fetal varicella syndrome (FVS) and neonatal varicella commenced with the June 2023 card. It is conducted by the UKHSA and led by Dr Gayatri Amirthalingam, and studies how many babies have FVS or neonatal varicella, the features of the diseases, the treatments babies receive and the outcomes of their disease. It aims to understand FVS and neonatal varicella in order to guide decisions about chicken pox vaccination, and to guide the treatment of these conditions. A parallel study is conducted in Portugal.
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Chronic recurrent multifocal osteomyelitis/ chronic nonbacterial osteomyelitis (CRMO/CNO)
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Listeria infection in infants
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Congenital syphilis 1
The BPSU survey of congenital syphilis began in July 1993. It aimed to undertake surveillance for congenital syphilis in the United Kingdom and the Republic of Ireland. At the time of the survey, the only surveillance of congenital syphilis was through the genitourinary medicine (GUM) clinics, and it was unclear whether all affected children might be attending such facilities.
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Invasive haemophilus influenzae infection following HIB Immunisation
In September 1992, the BPSU included invasive H influenzae infection occurring after Hib immunisation in its reporting scheme. In 1995, surveillance also included cases occurring in unvaccinated children. The data collected allowed the estimation of vaccine effectiveness, in relation to both the pre-vaccine era and incidence of cases in the unvaccinated population. In the later years of the study, there was confidence that estimates of efficacy truly represented the effect of the primary infant series.
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Measles, mumps, rubella-meningoencephalitis (MMR)
Active surveillance of mumps vaccine-associated meningoencephalitis was initiated in 1990 through the BPSU. BPSU reporters in the British Isles were asked to report cases of meningoencephalitis in children under 16 years of age occurring within six weeks of receiving the MMR vaccine.
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Congenital toxoplasmosis 1
At the time of the study, there was a debate about whether there should be a prenatal screening programme for toxoplasmosis in the UK. This study aimed to determine the number of cases in the British Isles.
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AIDs / HIV (HIV infection and vertical HIV exposure)
National surveillance of HIV infection and vertical HIV exposure was carried out by the NSHPC and covered all infants born to HIV positive women in the UK and Ireland, as well as all children diagnosed with HIV (regardless of country of birth) before the age of 16. The BPSU provided case notifications to the NSHPC, facilitating data collection for national HIV paediatric surveillance. Data collected contributed to a wide range of epidemiological and clinical analyses and publications, including assessments of the impact of antenatal screening and the uptake of interventions in pregnancy and the monitoring of developments in the management of infected and exposed children.
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